Peripheral neuropathy

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  • i. Impairment of motor function
    • 1. most polyneuropathies have weakness or paralysis as a component – usually the feet and legs are affected first before the hands and forearms with atrophy of affected muscles over several months
  • ii. tendon reflexes as a rule are lost or at least lessened
  • iii. fasciculations, cramps and spasms may occur with increases in activity making these symptoms worse
  • iv. polyneuropathy is affected symmetrically in the distal segments of the limbs with more involvement in legs than arms; vibratory sense is lost more than position and tactile sense but pain and temperature sensation is lost over touch, vibratory and position senses
  • v. paresthesias, pain and dysesthesias are common and may cause either a pins and needles type of feeling or pain
  • vi. peripheral neuropathy is the most common neurologic complication of chronic renal failure
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