Multiple endocrine neoplasia

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(all autosomal dominant)

1. Three types:
   1. MEN I (Wermer's Syndrome)– tumors of the anterior pituitary, parathyroids and pancreatic islets
      1. Chromosome defect is on chromosome 11q
      2. May also include schwannomas and small intestinal carcinoids
   2. MEN IIa (Sipple's Syndrome) and b
      1. Both groups display medullary thyroid carcinoma and pheochromocytomas
      2. MEN IIa also includes parathyroid hyperplasia
         1. Associated with chromosome losses on chromosome 1 and 10; Remember: these sum up to 11 which is the chromosome MEN I is found on
      3. MEN IIb also includes mucosal neuromas, ganglioneuromatosis of the GI tract and Marfan-like habitus